The most nervous thing for parents who do IVF is "Is the embryo good this time, is there any chance of pregnancy?". According to clinical observation, most implantation failures are related to embryo quality. In addition to performing preimplantation chromosome screening (PGS/PGT-A), how do embryologists judge the quality of embryos? Embryologists regularly observe the shape of the embryos and use "Morphology" to determine the quality of the embryos as a basis for predicting the implantation rate. Observation of embryo grade from embryo days In the case of natural conception, after the egg and sperm combine in the fallopian tube to become a fertilized egg, it will move to the uterine cavity while dividing, and implants in the inner wall of the uterus about the seventh day after fertilization. During the IVF treatment, the embryologist will observe the developmental status of the embryos on the first, third and fifth days, and select the time points for embryo implantation in D3 and D5 according to the embryo grade.
How are D3 Cell fragment ratio] In the grade of D3 embryos, the number is the number of cells (Blastomere). Under normal circumstances, the embryo will develop more than 6-8 cells. The first English letter represents cell symmetry, which is divided into two levels: Grade A: Cells of the same size Grade C: Inconsistent cell size The second English letter number list is the fragment around the cell (Fragment), which has four grades of A, B, C and D: A: High quality, no fragments or less than 5% fragments B: Excellent, with fragments accounting for 10%-20% C: Ordinary, fragments account for 20%-50% D: Poor, the proportion of fragments exceeds 50% During early embryonic development, cytoplasmic debris is often generated during cell division. Excessive cytoplasmic debris can affect the development of the embryo and may also represent abnormal chromosomes in the embryo. How are D5 embryos graded? trophoblast cells more ← → less A B C Inside thin cell group many.
The first English letter is the classification of the inner cell mass (ICM morphology): A: The number of cells is large and the arrangement is tight B: The number of cells is small and the arrangement is loose C: few cells The second English letter is the classification of trophoblast cells (TE morphology): A: The number of cells is large and the arrangement is tight B: The number of cells is small and the arrangement is loose C: few cells The better quality blastocysts can be expected to have a better implantation rate, which also means that the embryos develop better shape. Maosheng Hospital also has another set of D5 embryo grading method, which is more diverse and more precise, ensuring that embryologists can predict embryo implantation rates more comprehensively. Are higher embryo grades better? The better the grade of the embryo, the higher the success rate of embryo implantation. According to one study, embryos were graded into 4 groups. Good quality embryos (AA) Good embryos (AB, BA) General embryos (BB, AC, CA) Poor embryos (other grades) The researchers performed preimplantation chromosomal screening (PGS/PGT-A) on the embryos.